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KMID : 0377619730240060635
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Korean Jungang Medical Journal
1973 Volume.24 No. 6 p.635 ~ p.639
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The Effects of Chlorpromazine and Reserpine on the Glucose Metabolism and Serum Transaminase Activities in Rabbits
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申庚澈/Shin, Kyung Chul
朴貞仁/玄德燁/洪權熹/Park, Jung In/Hyun, Duk Yeup/Hong, Kwon Hee
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Abstract
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It is well known that both of chlorpromazine and reserpine liberate the catecholamine from various organs. But the liberating mechanism of catecholamine of each is different. So called, chlorpromazine inhibits the uptake of catecholamine and reserpine depletes the catecholamine from it´s store site.
The effect of chlorpromazine and reserpine on the metabolism is still not well known. So in this paper, the authors attempt to investigate the effect of those agents on the glucose metabolism and transaminase activities in rabbits.
The results were obtained as follows
1. The blood sugar levels in rabbits treated with chlorpromazine and reserpine relatively tend to increase, but the increasing rate of blood sugar is marked in reserpine treated rabbits.
2. Both of chlorpromazine and reserpine have a tendency to increase the activities of serum transaminases in rabbits. The serum GOT activities in rabbits treated with reserpine prior to experiment 24 hours are markedly increased but the serum GPT activities are significantly increased in 1 hour after injection of both agents.
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